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Blockade of Ca2+ and K+ currents in bag cell neurons of Aplysia californica by dihydropyridine Ca2+ antagonists

JM Nerbonne and AM Gurney
Journal of Neuroscience 1 March 1987, 7 (3) 882-893; https://doi.org/10.1523/JNEUROSCI.07-03-00882.1987
JM Nerbonne
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AM Gurney
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Abstract

The effects of dihydropyridine calcium antagonists on whole-cell Ca2+ and K+ currents in the neurosecretory bag cells of the marine mollusc Aplysia californica have been investigated. Nifedipine and nisoldipine blocked bag cell Ca2+ currents with effects similar to those seen previously on Ca2+ currents in cardiac muscle: both compounds appeared to interact with Ca2+ channels when they were closed, open, and inactivated. Also, as seen in cardiac cells, nifedipine apparently binds with higher affinity to Ca2+ channels when they are inactivated than when they are either closed or open. Nifedipine and nisoldipine also inhibited 2 outward K+ currents in bag cells: the “delayed rectifier” (IK) and the “A” (IA) currents. Half-maximal blockade of Ca2+ currents occurred at approximately 1.4 microM nifedipine, compared to approximately 3–5 microM for half-maximal blockade of IK and IA. The effects of these compounds on bag cell Ca2+ and K+ currents are interpreted and discussed here in terms of the “modulated receptor” model of drug action. In contrast, however, no measurable effects of nifedipine or nisoldipine were seen on Ca2+ (and/or K+) currents in several vertebrate neuronal cell types. Our results suggest that there are likely to be structural and/or conformational variations in Ca2+ channels in different cells, tissues, and/or species and also that, in some cells, Ca2+ and K+ channels might be structurally similar. These findings also suggest, therefore, that if dihydropyridine binding is used to identify Ca2+ channels, care should be taken to ensure that binding correlates closely with the Ca2+ channels of interest.

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The Journal of Neuroscience: 7 (3)
Journal of Neuroscience
Vol. 7, Issue 3
1 Mar 1987
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Blockade of Ca2+ and K+ currents in bag cell neurons of Aplysia californica by dihydropyridine Ca2+ antagonists
JM Nerbonne, AM Gurney
Journal of Neuroscience 1 March 1987, 7 (3) 882-893; DOI: 10.1523/JNEUROSCI.07-03-00882.1987

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Blockade of Ca2+ and K+ currents in bag cell neurons of Aplysia californica by dihydropyridine Ca2+ antagonists
JM Nerbonne, AM Gurney
Journal of Neuroscience 1 March 1987, 7 (3) 882-893; DOI: 10.1523/JNEUROSCI.07-03-00882.1987
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