Article Information
- Received March 25, 2019
- Revision received June 26, 2019
- Accepted July 22, 2019
- First published July 30, 2019.
- Version of record published October 2, 2019.
Author Information
- Ramón Martínez-Mármol1,
- Nika Mohannak1,*,
- Lei Qian1,2,*,
- Tong Wang1,
- Rachel S. Gormal1,
- Marc J. Ruitenberg2,
- Bart Vanhaesebroeck3,
- Elizabeth J. Coulson1,2, and
- Frédéric A. Meunier1
- 1Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia,
- 2School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane 4072, Australia, and
- 3Cell Signalling, University College London Cancer Institute, London WC1E 6DD, United Kingdom
Author contributions
Author contributions: R.M.-M., B.V., E.J.C., and F.A.M. designed research; R.M.-M., N.M., L.Q., T.W., and R.S.G. performed research; R.M.-M., N.M., M.J.R., E.J.C., and F.A.M. analyzed data; R.M.-M. and N.M. wrote the first draft of the paper; R.M.-M., T.W., R.S.G., M.J.R., B.V., E.J.C., and F.A.M. edited the paper; R.M.-M. and F.A.M. wrote the paper.
↵*N.M. and L.Q. contributed equally to this work.
Disclosures
- Received March 25, 2019.
- Revision received June 26, 2019.
- Accepted July 22, 2019.
This work was supported by the National Health and Medical Research Council (NHMRC) (Project Grants 1049236 to E.J.C., 1005964 to F.A.M., and 1060538 to M.J.R.). Work in the laboratory of B.V. is supported by the Biotechnology and, Biological Sciences Research Council (BB/I007806/1), Cancer Research UK (C23338/A25722) and the National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre. F.A.M. is supported by an NHMRC Senior Research Fellowship (569596). R.M.-M. is supported by the Clem and Jones Foundation, the State Government of Queensland, and the NHMRC Boosting Dementia Research Initiative. T.W. is supported by a Discovery Early Career Researcher Fellowship (DE170100546). M.J.R. is supported by a SpinalCure Australia Career Development Fellowship. We thank members of the Meunier and Coulson laboratories for technical assistance; Rumelo Amor for expert help with microscopy; Alan Ho, Pranesh Padmanabhan, and Tristan Wallis for expert help with statistical analysis; Rodrigo Medeiros and Judit Camats for providing frozen mouse brain samples; Nick Valmas for graphic design; Rowan Tweedale for critical reading and editing of the manuscript; UniQuest and the Queensland Emory Drug Discovery Initiative team for commercial insights and technical assistance; and the technical staff of the University of Queensland's Biological Resources and the Queensland Brain Institute animal facility for maintaining the various mouse lines used in this study.
B.V. is a consultant for Karus Therapeutics (Oxford, UK), iOnctura (Geneva, Switzerland), and Venthera (Palo Alto, California) and received speaker fees from Gilead (Foster City, California). The remaining authors declare no competing financial interests.
- Correspondence should be addressed to Frédéric A. Meunier at f.meunier{at}uq.edu.au or Elizabeth J. Coulson at e.coulson{at}uq.edu.au
Other Version
- previous version (July 30, 2019).
- You are viewing the most recent version of this article.
Online Impact