Article Information
- Received May 2, 2019
- Revision received December 12, 2019
- Accepted December 13, 2019
- First published January 2, 2020.
- Version of record published February 12, 2020.
Author Information
- Irune Diaz-Aparicio1,2,
- Iñaki Paris1,2,
- Virginia Sierra-Torre1,2,
- Ainhoa Plaza-Zabala1,
- Noelia Rodríguez-Iglesias1,2,
- Mar Márquez-Ropero1,2,
- Sol Beccari1,2,
- Paloma Huguet1,2,
- Oihane Abiega1,2,
- Elena Alberdi1,2,
- Carlos Matute1,2,
- Irantzu Bernales2,
- Angela Schulz3,
- Lilla Otrokocsi4,
- Beata Sperlagh4,
- Kaisa E. Happonen5,6,
- Greg Lemke5,6,
- Mirjana Maletic-Savatic7,8,
- Jorge Valero1,2,9, and
- Amanda Sierra1,2,9
- 1Achucarro Basque Center for Neuroscience, Leioa, Bizkaia 48940, Spain,
- 2University of the Basque Country UPV/EHU, Leioa, Bizkaia 48940, Spain,
- 3Rudolf-Schönheimer-Institute of Biochemistry, Medical Faculty, University Leipzig 04109, Germany,
- 4Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H-1083, Hungary,
- 5Molecular Neurobiology Laboratory,
- 6Immunobiology and Microbial Pathogenesis Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037,
- 7Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030,
- 8Department of Pediatrics and Neuroscience, Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, and
- 9Ikerbasque Foundation, Bilbao, Bizkaia 48013, Spain
Author contributions
Author contributions: I.D.-A., I.P., J.V., and A. Sierra designed research; I.D.-A., I.P., V.S.-T., A.P.-Z., N.R.-I., M.M.-R., S.B., P.H., O.A., E.A., I.B., L.O., K.E.H., J.V., and A. Sierra performed research; I.D.-A., I.P., I.B., J.V., and A. Sierra analyzed data; C.M., B.S., G.L., and A. Sierra contributed unpublished reagents/analytic tools; I.D.-A., I.P., V.S.-T., A.P.-Z., N.R.-I., M.M.-R., S.B., A. Schulz, L.O., B.S., K.E.H., G.L., M.M.-S., J.V., and A. Sierra wrote the paper.
Disclosures
- Received May 2, 2019.
- Revision received December 12, 2019.
- Accepted December 13, 2019.
This work was supported by grants from the Spanish Ministry of Economy and Competitiveness (http://www.mineco.gob.es) with FEDER funds to A.S. (BFU2012-32089 and RYC-2013-12817) to A.S. and J.V. (BFU2015-66689); a Leonardo Award from the BBVA Foundation to A.S. (IN16,_BBM_BAS_0260); a Basque Government Department of Education project to A.S. (PI_2016_1_0011; http://www.euskadi.eus/basque-government/department-education/); Ikerbasque start-up funds to J.V.; a Hungarian Research and Development Fund Grant (K116654) to B.S.; a Hungarian Brain Research Program Grant (2017-1.2.1-NKP-2017-00002) to B.S.; a National Institutes of Health Grant (AG060748) to G.L. In addition, I.D.-A., N.R.-I., and M.M.-R. are recipients of pre-doctoral fellowships from the University of the Basque Country EHU/UPV (http://www.ehu.eus/en/en-home); I.P. is a recipient of a Gangoiti Foundation Fellowship; S.B. is recipients of pre-doctoral fellowship from the Spanish Ministry of Economy and Competitiveness; V.S.-T. and O.A. are recipients of pre-doctoral fellowship from the Basque Government; and A.P.-Z. is the recipient of a Juan de la Cierva postdoctoral fellowship from the Spanish Ministry of Economy and Competitiveness. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript; UPV/EHU SGIker technical and human support is gratefully acknowledged. We thank Victor Sánchez Zafra for technical support, and Isabel Fariñas, María Domercq, and Ismael Galve-Roperh for thoughtful discussion of the data.
The authors declare no competing financial interests.
- Correspondence should be addressed to Amanda Sierra at amanda.sierra{at}achucarro.org or Jorge Valero at jorge.valero{at}achucarro.org
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