Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

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¹Department of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD, USA.
²Department of Chemical, Biochemical & Environmental Engineering, University of Maryland, Baltimore County, Maryland, USA
³Division of Translational Radiation Sciences (DTRS), Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.
⁴VA Maryland Health Care System, Baltimore VA Medical Center, Baltimore MD
⁵School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.

Address correspondence to: Rebecca J. Henry, Ph.D., Department of Anesthesiology, University of Maryland School of Medicine, 685 West Baltimore Street, MSTF #6-02, MD 21201. Tel: 410-706-4205. E-mail: rhenry{at}som.umaryland.edu; David J. Loane, Ph.D., School of Biochemistry and Immunology, Trinity College, Room 5.08C, 152-160 Pearse Street, Dublin, Ireland, D02R590. E-mail: loanedj{at}tcd.ie

Author contributions: R.J.H., B.A.S., and D.J.L. designed research; R.J.H., R.M.R., J.P.B., and S.J.D. performed research; R.J.H., R.M.R., J.P.B., S.J.D., Y.J., J.B.L., G.S., B.A.S., and D.J.L. analyzed data; R.J.H. wrote the first draft of the paper; G.S., A.I.F., and D.J.L. edited the paper; J.W. contributed unpublished reagents/analytic tools; D.J.L. wrote the paper.

The authors declare no competing financial interests.
The authors thank Victoria Meadows and Wesley Shoap for help with neurobehavioral assessment and histology. The authors thank Plexxikon Inc. for the use of PLX5622. This work was supported by National Institutes of Health grants R01NS082308 (D.J.L), R01NS037313 (A.I.F), R01NS096002 (B.A.S), and R01NS110756 (D.J.L./A.I.F/B.A.S), R21EY029451 (J.B.L), a U.S. Veterans Affairs grant 1I01 RX001993 (B.A.S), and Science Foundation Ireland grant 17/FRL/4860 (D.J.L).

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