Article Information
- Received March 2, 2021
- Revision received August 15, 2021
- Accepted August 22, 2021
- First published September 2, 2021.
- Version of record published October 20, 2021.
Author Information
- Sarayu Ramakrishna1,2,7,
- Vishwaja Jhaveri1,
- Sabine C. Konings3,
- Bharti Nawalpuri1,6,7,
- Sumita Chakraborty1,
- Bjørn Holst4,
- Benjamin Schmid4,
- Gunnar K. Gouras3,
- Kristine K. Freude5, and
- Ravi S. Muddashetty1,7
- 1Institute for Stem Cell Science and Regenerative Medicine, Bangalore 560065, India
- 2The University of Trans-Disciplinary Health Sciences and Technology (TDU), Bangalore 560064, India
- 3Experimental Dementia Research Unit, Department of Experimental Medical Science, Lund University, Lund 22184, Sweden
- 4Bioneer A/S, Hørsholm 2970, Denmark
- 5Department of Veterinary and Animal Sciences, Group of Stem Cell Models for Studies of Neurodegenerative Diseases, Section for Pathobiological Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
- 6The Shanmugha Arts, Science, Technology and Research Academy, Thanjavur 613401, India
- 7Centre for Brain Research, Indian Institute of Science Campus, Bangalore 560012, India
Author contributions
Author contributions: S.R., S.C.K., G.K.G., K.K.F., and R.S.M. designed research; S.R., V.J., S.C.K., B.N., S.C., and R.S.M. performed research; B.H., B.S., G.K.G., K.K.F., and R.S.M. contributed unpublished reagents/analytic tools; S.R., V.J., S.C.K., and S.C. analyzed data; S.R. and R.S.M. wrote the first draft of the paper; S.R., G.K.G., K.K.F., and R.S.M. edited the paper; S.R. and R.S.M. wrote the paper.
Disclosures
- Received March 2, 2021.
- Revision received August 15, 2021.
- Accepted August 22, 2021.
This work was supported by the NeuroStem Grant BT/IN/Denmark/07/RSM/2015-2016. S.R. was supported by the Junior/Senior Research Fellowship DBT/2016/InStem/540 from the Department of Biotechnology (DBT). G.K.G. was supported by the EU H2020 Marie Sklodowska–Curie Grant 721802 (SYNDEGEN) and the Swedish Research Council Grant 2019-01125. S.C.K. was supported by the EU H2020 Marie Sklodowska–Curie Grant 721802 (SYNDEGEN). We thank all the central facilities at NCBS-inStem, especially the Central Imaging and Flow Cytometry Facility (CIFF), Animal House Facility, and Stem Cell Facility; our collaborators and colleagues for their invaluable suggestions and discussions; specially Dr. Sumantra Chattarji and his lab members from National Center for Biological Sciences, Bangalore, for all the technical help and conceptual scientific discussions; Dr. James Chelliah from JNCASR, Bangalore, for giving us MK801; and thank Dr. Vijayalakshmi Ravindranath and Dr. Reddy P. Kommaddi from Centre for Brain Research, Bangalore, for their generous gift of MAP2 antibody and B27 during the revision experiments.
The authors declare no competing financial interests.
- Correspondence should be addressed to Ravi S. Muddashetty at ravism{at}instem.res.in or ravimshetty{at}iisc.ac.in
Funding
Department of Biotechnology, Ministry of Science and Technology (DBT)
BT/IN/Denmark/07/RSM/2015-2016; DBT/2016/InStem/540EU H2020 Marie Sklodowska-Curie grant
721802; 721802Svenska Forskningsrådet Formas (Swedish Research Council Formas)
2019-01125
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