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Research Articles, Systems/Circuits

Ventral tegmental area dopamine neural activity switches simultaneously with rule representations in the medial prefrontal cortex and hippocampus

Mingxin Ding, Porter L. Tomsick, Ryan A. Young and Shantanu P. Jadhav
Journal of Neuroscience 17 March 2025, e1670242025; https://doi.org/10.1523/JNEUROSCI.1670-24.2025
Mingxin Ding
1Graduate Program in Neuroscience, Brandeis University, Waltham, MA 02453, USA
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Porter L. Tomsick
2Undergraduate Program in Neuroscience, Brandeis University, Waltham, MA 02453, USA
3Department of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
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Ryan A. Young
4Department of Psychology, Brandeis University, Waltham, MA, 02453, USA
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Shantanu P. Jadhav
1Graduate Program in Neuroscience, Brandeis University, Waltham, MA 02453, USA
4Department of Psychology, Brandeis University, Waltham, MA, 02453, USA
5Volen National Center for Complex Systems, Brandeis University, Waltham, MA, 02453, USA
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1670-24.2025
Published By 
Society for Neuroscience
History 
  • Received June 21, 2024
  • Revision received February 26, 2025
  • Accepted March 8, 2025
  • First published March 17, 2025.
Copyright & Usage 
Copyright © 2025 Ding et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Mingxin Ding1,
  2. Porter L. Tomsick2,3,
  3. Ryan A. Young4, and
  4. Shantanu P. Jadhav1,4,5
  1. 1Graduate Program in Neuroscience, Brandeis University, Waltham, MA 02453, USA
  2. 2Undergraduate Program in Neuroscience, Brandeis University, Waltham, MA 02453, USA
  3. 3Department of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
  4. 4Department of Psychology, Brandeis University, Waltham, MA, 02453, USA
  5. 5Volen National Center for Complex Systems, Brandeis University, Waltham, MA, 02453, USA
  1. Correspondence should be addressed to Shantanu P. Jadhav at shantanu{at}brandeis.edu

Author contributions

  1. Author Contributions: M.D. and S.P.J. conceptualized the study; M.D. and P.L.T. performed the experiments; M.D. analyzed the data; R.A.Y. contributed to analysis packages; M.D. and S.P.J. wrote the manuscript.

Disclosures

  • This work was supported by the National Institutes of Health (R01MH112661) to S.P.J. and a T90 training grant (R90DA033463). We would like to thank Dr. Naoshige Uchida, Dr. Joshua Berke and Dr. Ali Mohebi for the protocol of the opto-tagging experiment, Dr. John Bladon and Audrey Hooker for piloting the W-track rule switching task, Dr. Justin Shin in assisting in implant surgeries, Dr. Wenbo Tang, Dr. Jacob Olson, Dr. Blake Porter and other lab members in providing feedback on the research project.

  • Authors report no conflict of interest.

Funding

  • HHS | NIH | National Institute of Mental Health (NIMH)

    R01MH112661
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R90DA033463

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Ventral tegmental area dopamine neural activity switches simultaneously with rule representations in the medial prefrontal cortex and hippocampus
Mingxin Ding, Porter L. Tomsick, Ryan A. Young, Shantanu P. Jadhav
Journal of Neuroscience 17 March 2025, e1670242025; DOI: 10.1523/JNEUROSCI.1670-24.2025

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Ventral tegmental area dopamine neural activity switches simultaneously with rule representations in the medial prefrontal cortex and hippocampus
Mingxin Ding, Porter L. Tomsick, Ryan A. Young, Shantanu P. Jadhav
Journal of Neuroscience 17 March 2025, e1670242025; DOI: 10.1523/JNEUROSCI.1670-24.2025
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