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Research Articles, Cellular/Molecular

Leptin activates dopamine and GABA neurons in the substantia nigra via a local pars compacta-pars reticulata circuit

Maria Mancini, Takuya Hikima, Paul Witkovsky, Jyoti C. Patel, Dominic W. Stone, Alison H. Affinati and Margaret E. Rice
Journal of Neuroscience 24 March 2025, e1539242025; https://doi.org/10.1523/JNEUROSCI.1539-24.2025
Maria Mancini
1Department of Neuroscience and Physiology, NYU School of Medicine, New York, NY, USA
2Neuroscience Institute, NYU School of Medicine, New York, NY, USA
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Takuya Hikima
3Department of Neurosurgery, NYU School of Medicine, New York, NY, USA
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Paul Witkovsky
3Department of Neurosurgery, NYU School of Medicine, New York, NY, USA
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Jyoti C. Patel
2Neuroscience Institute, NYU School of Medicine, New York, NY, USA
3Department of Neurosurgery, NYU School of Medicine, New York, NY, USA
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Dominic W. Stone
3Department of Neurosurgery, NYU School of Medicine, New York, NY, USA
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Alison H. Affinati
4Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
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Margaret E. Rice
1Department of Neuroscience and Physiology, NYU School of Medicine, New York, NY, USA
2Neuroscience Institute, NYU School of Medicine, New York, NY, USA
3Department of Neurosurgery, NYU School of Medicine, New York, NY, USA
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  • For correspondence: margaret.rice@nyu.edu
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1539-24.2025
Published By 
Society for Neuroscience
History 
  • Received August 10, 2024
  • Revision received February 28, 2025
  • Accepted March 16, 2025
  • First published March 24, 2025.
Copyright & Usage 
Copyright © 2025 the authors SfN exclusive license.

Author Information

  1. Maria Mancini1,2,
  2. Takuya Hikima3,
  3. Paul Witkovsky3,
  4. Jyoti C. Patel2,3,
  5. Dominic W. Stone3,
  6. Alison H. Affinati4, and
  7. Margaret E. Rice1,2,3,*
  1. 1Department of Neuroscience and Physiology, NYU School of Medicine, New York, NY, USA
  2. 2Neuroscience Institute, NYU School of Medicine, New York, NY, USA
  3. 3Department of Neurosurgery, NYU School of Medicine, New York, NY, USA
  4. 4Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
  1. ↵*Correspondence should be addressed to Margaret E. Rice at margaret.rice{at}nyu.edu

Author contributions

  1. Author contributions: M.M., T.H., P.W., J.P., and M.R. designed research; M.M., T.H., P.W., D.S., and A.A. performed research; M.M., T.H., P.W., J.P., and M.R. analyzed data; M.M., T.H., P.W., and M.R. edited the paper; M.M. and M.R. wrote the paper; A.A. contributed unpublished reagents/analytic tools.

Disclosures

  • The authors declare no competing financial interests.

  • Funding was provided by the Marlene and Paolo Fresco Institute for Parkinson’s Disease and Movement Disorders, including a postdoctoral fellowship to M.M., and by National Institutes of Health grants DA050165 (M.E.R.) and DK122660 (A.H.A.). We are grateful to Martin G. Myers Jr. at the University of Michigan for providing LepRbEGFP mice utilized in this study, to Adam C. Mar at the NYU Grossman School of Medicine for advice on the locomotor experiments, and to Riccardo Melani for advice on statistical analyses.

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    DA050165
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    DK122660

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Leptin activates dopamine and GABA neurons in the substantia nigra via a local pars compacta-pars reticulata circuit
Maria Mancini, Takuya Hikima, Paul Witkovsky, Jyoti C. Patel, Dominic W. Stone, Alison H. Affinati, Margaret E. Rice
Journal of Neuroscience 24 March 2025, e1539242025; DOI: 10.1523/JNEUROSCI.1539-24.2025

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Leptin activates dopamine and GABA neurons in the substantia nigra via a local pars compacta-pars reticulata circuit
Maria Mancini, Takuya Hikima, Paul Witkovsky, Jyoti C. Patel, Dominic W. Stone, Alison H. Affinati, Margaret E. Rice
Journal of Neuroscience 24 March 2025, e1539242025; DOI: 10.1523/JNEUROSCI.1539-24.2025
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