Development/Plasticity/Repair

Developmental Modulation of Retinal Wave Dynamics: Shedding Light on the GABA Saga

Evelyne Sernagor, Carol Young and Stephen J. Eglen
Journal of Neuroscience 20 August 2003, 23 (20) 7621-7629; DOI: https://doi.org/10.1523/JNEUROSCI.23-20-07621.2003

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Files in this Data Supplement:

  • Supplementary Movie 1 - Spontaneous wave of activity in the RGC layer in a S23 retina. Cells were back-labeled with CGD. The background fluorescence has been subtracted from the images, so that only increases in fluorescence, associated with Ca2+ and electrical activity are visible (played back in real time). The wave is fast and widespreading.
  • Supplementary Movie 2 - Spontaneous wave of activity in the RGC layer in a S25 retina. The wave is much slower and more winding than at S23.
  • Supplementary Movie 3 - GABA-induced wave of activity in the RGC layer in a S25 retina. Here the activity is not spontaneous, but rather induced by a puff of GABA (50 �M) in the chamber. The activity is played back 4 times faster than real time.
  • Supplementary Movie 4 - Spontaneous activity in the RGC layer in a DR4 retina. The activity exhibits both patches and propagation. In normal rearing conditions, there is no correlated spontaneous activity anymore at this stage.

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