PT  - JOURNAL ARTICLE
AU  - Maxime Bonjean
AU  - Tanya Baker
AU  - Maxime Lemieux
AU  - Igor Timofeev
AU  - Terrence Sejnowski
AU  - Maxim Bazhenov
TI  - Corticothalamic Feedback Controls Sleep Spindle Duration <em>In Vivo</em>
AID  - 10.1523/JNEUROSCI.0077-11.2011
DP  - 2011 Jun 22
TA  - The Journal of Neuroscience
PG  - 9124--9134
VI  - 31
IP  - 25
4099  - http://www.jneurosci.org/content/31/25/9124.short
4100  - http://www.jneurosci.org/content/31/25/9124.full
SO  - J. Neurosci.2011 Jun 22; 31
AB  - Spindle oscillations are commonly observed during stage 2 of non-rapid eye movement sleep. During sleep spindles, the cerebral cortex and thalamus interact through feedback connections. Both initiation and termination of spindle oscillations are thought to originate in the thalamus based on thalamic recordings and computational models, although some in vivo results suggest otherwise. Here, we have used computer modeling and in vivo multisite recordings from the cortex and the thalamus in cats to examine the involvement of the cortex in spindle oscillations. We found that although the propagation of spindles depended on synaptic interaction within the thalamus, the initiation and termination of spindle sequences critically involved corticothalamic influences.