RT Journal Article
SR Electronic
T1 Cardioactive neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) and novel related peptides are encoded in multiple copies by a single gene in the snail Lymnaea stagnalis
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 412
OP 419
DO 10.1523/JNEUROSCI.10-02-00412.1990
VO 10
IS 2
A1 Linacre, A
A1 Kellett, E
A1 Saunders, S
A1 Bright, K
A1 Benjamin, PR
A1 Burke, JF
YR 1990
UL http://www.jneurosci.org/content/10/2/412.abstract
AB The neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) is a potent cardioactive neuropeptide in Lymnaea stagnalis. Isolation and sequencing of 2 cDNAs and a genomic clone shows that a single gene encodes a precursor protein which contains 9 copies of the FMRFamide peptide, 2 copies of the related peptide Phe-Leu-Arg-Phe-NH2 (FLRFamide), and single copies of the putative pentapeptides Gln-Phe- Tyr-Arg-lle-NH2 (posttranslationally modified to pQFYRlamide) and Glu- Phe-Leu-Arg-lle-NH2 (EFLRlamide). The gene is transcribed in the CNS and gives rise to a single RNA of 1.7 kb in size. The organization of the Lymnaea gene is significant with respect to the evolution of FMRFamide and related peptides in other organisms.