RT Journal Article
SR Electronic
T1 Differentiation of IKA in amphibian spinal neurons
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 1886
OP 1891
DO 10.1523/JNEUROSCI.10-06-01886.1990
VO 10
IS 6
A1 AB Ribera
A1 NC Spitzer
YR 1990
UL http://www.jneurosci.org/content/10/6/1886.abstract
AB We have examined the development of an inactivating outward current in embryonic amphibian neurons differentiating in culture. On the basis of ionic selectivity, voltage dependence of activation and inactivation and pharmacological sensitivity, it is similar to A currents described in other neurons. In these embryonic neurons the A current appears later than other voltage-dependent currents studied previously. Furthermore, its maturation extends to times later than those required for the differentiation of another potassium current, the voltage- dependent delayed rectifier. These changes in A current are consistent with parallel changes in the action potential and excitability of the developing neurons.