TY - JOUR T1 - Marked increases in large enkephalin-containing polypeptides in the rat adrenal gland following denervation JF - The Journal of Neuroscience JO - J. Neurosci. SP - 80 LP - 82 DO - 10.1523/JNEUROSCI.01-01-00080.1981 VL - 1 IS - 1 AU - RV Lewis AU - AS Stern AU - DL Kilpatrick AU - LD Gerber AU - J Rossier AU - S Stein AU - S Udenfriend Y1 - 1981/01/01 UR - http://www.jneurosci.org/content/1/1/80.abstract N2 - When rat adrenal glands are denervated, large increases in the amounts of enkephalin and enkephalin-containing polypeptides appear. In the normal gland, only trace amounts occur. One of the larger polypeptides (approximately 22,000 daltons) increases rapidly and by 48 hr following denervation, attains 20 times its original level. At this time, the levels of free enkephalins are essentially unchanged. By 96 hr, the 22,000-dalton polypeptide begins to decrease as free enkephalins and intermediate-sized enkephalin-containing polypeptides increase. This series of events is consistent with a precursor (22,000-dalton polypeptide)/product (enkephalin) relationship. ER -