PT  - JOURNAL ARTICLE
AU  - Salpeter, MM
AU  - Marchaterre, M
TI  - Acetylcholine receptors in extrajunctional regions of innervated muscle have a slow degradation rate
AID  - 10.1523/JNEUROSCI.12-01-00035.1992
DP  - 1992 Jan 01
TA  - The Journal of Neuroscience
PG  - 35--38
VI  - 12
IP  - 1
4099  - http://www.jneurosci.org/content/12/1/35.short
4100  - http://www.jneurosci.org/content/12/1/35.full
SO  - J. Neurosci.1992 Jan 01; 12
AB  - Scanning EM autoradiography was used to determine the degradation rate of extrajunctional ACh receptors (AChRs) in innervated sternomastoid muscles of the mouse. We report that in innervated muscles, extrajunctional AChRs have a slow degradation rate (t1/2, approximately 8 d), similar to that seen at the neuromuscular junction. We conclude that slowly degrading AChRs (Rs) need not be localized at the specialized structure of the nerve-muscle junction. Degradation of extrajunctional as well as junctional AChRs may depend primarily on the state of innervation of the muscle.