PT  - JOURNAL ARTICLE
AU  - KS Canady
AU  - EW Rubel
TI  - Rapid and reversible astrocytic reaction to afferent activity blockade in chick cochlear nucleus
AID  - 10.1523/JNEUROSCI.12-03-01001.1992
DP  - 1992 Mar 01
TA  - The Journal of Neuroscience
PG  - 1001--1009
VI  - 12
IP  - 3
4099  - http://www.jneurosci.org/content/12/3/1001.short
4100  - http://www.jneurosci.org/content/12/3/1001.full
SO  - J. Neurosci.1992 Mar 01; 12
AB  - We describe here rapid proliferation of astrocytic processes immunoreactive for glial fibrillary acidic protein (GFAP) in the chick cochlear nucleus following blockade of action potentials in the afferent nerve. Unilateral eighth nerve activity blockade was achieved through intralabyrinthine injection of TTX. Within 1 hr of activity blockade, a 56% increase in area density of GFAP-immunoreactive processes was found in the ipsilateral cochlear nucleus as compared to the contralateral side of the brain. This increase reached 152% by 3 hr. When eighth nerve activity was allowed to recover and animals were studied 1 week after TTX injection, no difference was found in GFAP immunoreactivity between the ipsilateral and contralateral cochlear nuclei. This is the first report of a glial reaction to documented neuronal inactivity in the absence of neuropathology. These results indicate that neuronal activity may regulate the structure of astrocytic processes.