PT  - JOURNAL ARTICLE
AU  - Huang, B
AU  - Karwoski, CJ
TI  - Light-evoked expansion of subretinal space volume in the retina of the frog
AID  - 10.1523/JNEUROSCI.12-11-04243.1992
DP  - 1992 Nov 01
TA  - The Journal of Neuroscience
PG  - 4243--4252
VI  - 12
IP  - 11
4099  - http://www.jneurosci.org/content/12/11/4243.short
4100  - http://www.jneurosci.org/content/12/11/4243.full
SO  - J. Neurosci.1992 Nov 01; 12
AB  - The retina of the frog was superfused with a Ringer solution containing impermeant “probe” cations and anions. Light-evoked concentration changes in these probe ions were measured in the subretinal space (SRS) with ion-selective microelectrodes. A decrease in probe ion concentration was found, and several observations suggest that this is caused by a light-evoked expansion of the SRS. The probe ion decrease was not seen in the isolated retina; thus, the pigment epithelial (PE) cells are important for its generation. Pharmacological studies suggest that K+ channels in the PE cells are important--perhaps the PE cells shrink in response to the light-evoked decrease in SRS [K+]. The light- evoked decrease of SRS volume may be important in the understanding of SRS solute concentrations, retina-PE adhesivity, photoreceptor-PE cell interactions, and the interphotoreceptor matrix.