TY - JOUR T1 - Muscarinic potentiation of IK in hippocampal neurons: electrophysiological characterization of the signal transduction pathway JF - The Journal of Neuroscience JO - J. Neurosci. SP - 4510 LP - 4520 DO - 10.1523/JNEUROSCI.12-11-04510.1992 VL - 12 IS - 11 AU - L Zhang AU - JL Weiner AU - PL Carlen Y1 - 1992/11/01 UR - http://www.jneurosci.org/content/12/11/4510.abstract N2 - Central cholinergic (muscarinic) systems play an important role in learning and memory. In mammalian central neurons, muscarinic stimulation depresses several voltage-activated K+ currents and modulates synaptic transmission. Using whole-cell voltage-clamp recordings in hippocampal CA1 neurons of rat brain slices, we report that activation of muscarinic receptors potentiates a voltage- activated, sustained K+ current (IK-type). This potentiation of IK is mediated by activation of protein kinase C and involves a G-protein- linked, intracellular Ca(2+)-dependent process. This underlying second messenger pathway may prove to be important in the mediation of other previously reported muscarinic neuronal actions. ER -