PT  - JOURNAL ARTICLE
AU  - P Camacho
AU  - Y Liu
AU  - G Mandel
AU  - P Brehm
TI  - The epsilon subunit confers fast channel gating on multiple classes of acetylcholine receptors
AID  - 10.1523/JNEUROSCI.13-02-00605.1993
DP  - 1993 Feb 01
TA  - The Journal of Neuroscience
PG  - 605--613
VI  - 13
IP  - 2
4099  - http://www.jneurosci.org/content/13/2/605.short
4100  - http://www.jneurosci.org/content/13/2/605.full
SO  - J. Neurosci.1993 Feb 01; 13
AB  - During vertebrate skeletal muscle development, multiple forms of long- open-time (slow-type) ACh receptor channels are replaced by at least two different types of short-open-time (fast-type) ACh receptors. Expression of ACh receptors in Xenopus oocytes indicates that the substitution of an epsilon subunit for a gamma subunit may account for both types of fast-gated channel types in adult muscle. Unlike the various forms of the embryonic receptor, in which functional diversity is achieved through alterations in subunit composition, the two major fast-gated forms expressed in oocytes have identical subunit composition. These findings provide a structural basis for both types of short-open-time ACh receptor types found in adult muscle.