RT Journal Article
SR Electronic
T1 The epsilon subunit confers fast channel gating on multiple classes of acetylcholine receptors
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 605
OP 613
DO 10.1523/JNEUROSCI.13-02-00605.1993
VO 13
IS 2
A1 P Camacho
A1 Y Liu
A1 G Mandel
A1 P Brehm
YR 1993
UL http://www.jneurosci.org/content/13/2/605.abstract
AB During vertebrate skeletal muscle development, multiple forms of long- open-time (slow-type) ACh receptor channels are replaced by at least two different types of short-open-time (fast-type) ACh receptors. Expression of ACh receptors in Xenopus oocytes indicates that the substitution of an epsilon subunit for a gamma subunit may account for both types of fast-gated channel types in adult muscle. Unlike the various forms of the embryonic receptor, in which functional diversity is achieved through alterations in subunit composition, the two major fast-gated forms expressed in oocytes have identical subunit composition. These findings provide a structural basis for both types of short-open-time ACh receptor types found in adult muscle.