RT Journal Article SR Electronic T1 Multiple receptor systems promote CNS neural migration JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 3485 OP 3495 DO 10.1523/JNEUROSCI.13-08-03485.1993 VO 13 IS 8 A1 Fishman, RB A1 Hatten, ME YR 1993 UL http://www.jneurosci.org/content/13/8/3485.abstract AB To identify glial receptor systems in CNS migration, cerebellar granule neuron migration was assayed on glass fibers coated with polylysine, astroglial membranes (AM fibers), or the extracellular matrix proteins collagen (COLL fibers), fibronectin (FN fibers), and laminin (LAM fibers). By video microscopy, granule cells migrated along AM fibers with the cytology, neuron-fiber apposition, and dynamics seen on living glia. The demonstration that immobilized astroglial membranes support neural migration suggests that astroglial receptor systems, in combination with glial fiber geometry, promote CNS neural migration. Moreover, granule neurons migrated rapidly on LAM fibers, moved relatively slowly on FN fibers, and not at all on COLL fibers. Antibody perturbation analyses suggested that, whereas astrotactin provides the neural receptor for migration on astroglial membranes, integrin beta 1 provides the neural receptor for migration on LAM fibers. These results suggest that multiple receptor systems support CNS neural migration.