RT Journal Article
SR Electronic
T1 Strategies for the generation of neuronal diversity in the developing central nervous system
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 6987
OP 6998
DO 10.1523/JNEUROSCI.15-11-06987.1995
VO 15
IS 11
A1 SK McConnell
YR 1995
UL http://www.jneurosci.org/content/15/11/6987.abstract
AB During development, the neural tube produces a large diversity of neuronal phenotypes from a morphologically homogeneous pool of precursor cells. In recent years, the cellular and molecular mechanisms by which specific types of neurons are generated have been explored, in the hope of discovering features common to development throughout the nervous system. This article focuses on three strategies employed by the CNS to generate distinct classes of neuronal phenotypes during development: dorsal-ventral polarization in the spinal cord, segmentation in the hindbrain, and a lamination in the cerebral cortex. The mechanisms for neurogenesis exemplified by these three strategies range from a relatively rigid, cell lineage-dependent specification with a high degree of subservance to early patterns of gene expression, to inductions and cell-cell interactions that determine cell fates more flexibly.