RT Journal Article
SR Electronic
T1 Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 4687
OP 4692
DO 10.1523/JNEUROSCI.15-06-04687.1995
VO 15
IS 6
A1 Cameron, HA
A1 McEwen, BS
A1 Gould, E
YR 1995
UL http://www.jneurosci.org/content/15/6/4687.abstract
AB The effects of afferent input and N-methyl-D-aspartate (NMDA) receptor activation on neurogenesis were examined in an intact system, the rat dentate gyrus, where neurons are naturally born in the adult. In the adult dentate gyrus, activation of NMDA receptors rapidly decreased the number of cells synthesizing DNA, whereas blockade of NMDA receptors rapidly increased the number of cells in the S phase identified with 3H- thymidine. Acute treatment with NMDA receptor antagonists increased the birth of neurons and increased the overall density of neurons in the granule cell layer. Lesion of the entorhinal cortex, the main excitatory afferent population to the granule neurons, also increased the birth of cells in the dentate gyrus. These results suggest that adult neurogenesis in the dentate gyrus of the rat is altered by afferent input, via NMDA receptors, and may be regulated naturally by endogenous excitatory amino acids.