RT Journal Article
SR Electronic
T1 Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 5088
OP 5097
DO 10.1523/JNEUROSCI.15-07-05088.1995
VO 15
IS 7
A1 Chen, ZL
A1 Yoshida, S
A1 Kato, K
A1 Momota, Y
A1 Suzuki, J
A1 Tanaka, T
A1 Ito, J
A1 Nishino, H
A1 Aimoto, S
A1 Kiyama, H
YR 1995
UL http://www.jneurosci.org/content/15/7/5088.abstract
AB A novel murine cDNA which encodes a protein designated neuropsin was cloned. Northern and in situ hybridization analyses demonstrated that neuropsin mRNA is expressed specifically in the limbic system of mouse brain and is localized at highest concentration in pyramidal neurons of the hippocampal CA1–3 subfields. Direct hippocampal stimulation and kindling induced by amygdaloid stimulation caused a significant bilateral change in neuropsin mRNA level in the hippocampal pyramidal neurons. The activity-dependent changes and the specific localization indicate that neuropsin is involved in hippocampal plasticity.