TY - JOUR T1 - cAMP Levels Increased by Activation of Metabotropic Glutamate Receptors Correlate with Visual Plasticity JF - The Journal of Neuroscience JO - J. Neurosci. SP - 7619 LP - 7626 DO - 10.1523/JNEUROSCI.16-23-07619.1996 VL - 16 IS - 23 AU - Silvia N. M. Reid AU - Nigel W. Daw AU - Douglas S. Gregory AU - Helen Flavin Y1 - 1996/12/01 UR - http://www.jneurosci.org/content/16/23/7619.abstract N2 - We have investigated the cAMP level increased by stimulation of metabotropic glutamate receptors (mGluRs) in cat visual cortex during development. The cAMP level increases activated by the general mGluR agonist (1S,3R)-1-amino-1,3-cyclopentane-dicarboxylic acid (ACPD) were closely correlated with the critical period for ocular dominance plasticity in both light- and dark-reared animals. Activation of either group I or group II mGluRs increased the cAMP level. Group II mGluR activation also reduced the forskolin-stimulated cAMP increase. The correlation was emulated by a mixture of groups I, II, and III mGluR agonists but not by agonists applied singly; therefore, the correlation is attributable to activation of multiple groups of mGluRs. The cAMP level increased by the mixture was greater than the sum of the increases produced by the agonists applied singly (super-additive effect), suggesting an interaction between the G-proteins and/or second messengers controlled by these mGluRs. The basal cAMP level also correlated closely with the critical period until shortly after the peak of the critical period. Therefore, the major factor that contributes to the correlation between the ACPD-stimulated cAMP increase and the peak of the critical period is the basal level of cAMP: the activation of multiple mGluRs amplifies the basal cAMP. We suggest that both basal activity of cAMP production and activation of mGluRs may be important in plasticity in the visual cortex. ER -