PT - JOURNAL ARTICLE AU - Winkler, Christian AU - Sauer, Hansjörg AU - Lee, Chong S. AU - Björklund, Anders TI - Short-Term GDNF Treatment Provides Long-Term Rescue of Lesioned Nigral Dopaminergic Neurons in a Rat Model of Parkinson’s Disease AID - 10.1523/JNEUROSCI.16-22-07206.1996 DP - 1996 Nov 15 TA - The Journal of Neuroscience PG - 7206--7215 VI - 16 IP - 22 4099 - http://www.jneurosci.org/content/16/22/7206.short 4100 - http://www.jneurosci.org/content/16/22/7206.full SO - J. Neurosci.1996 Nov 15; 16 AB - Glial cell line-derived neurotrophic factor (GDNF) has been shown to exert neuroprotective effects on dopamine (DA) neurons in vivo. Here we report long-term rescue of nigral DA neurons after delayed short-term GDNF administration in a rat lesion model that reproduces the slowly progressing degenerative process seen in Parkinson’s disease. GDNF injected close to the substantia nigra provided near-complete protection and persistent survival of the lesioned nigral neurons for at least 4 months after discontinuation of GDNF treatment. Long-term rescue of the nigral cells, however, was not accompanied by any significant reinnervation of the lesioned striatal target or any signs of functional recovery in either drug-induced or spontaneous motor behaviors. We conclude that not only preservation of the nigral DA neurons but also restoration of striatal DA function is necessary for functional recovery in the rat Parkinson model.