PT - JOURNAL ARTICLE AU - Susan E. Brockerhoff AU - James B. Hurley AU - Gregory A. Niemi AU - John E. Dowling TI - A New Form of Inherited Red-Blindness Identified in Zebrafish AID - 10.1523/JNEUROSCI.17-11-04236.1997 DP - 1997 Jun 01 TA - The Journal of Neuroscience PG - 4236--4242 VI - 17 IP - 11 4099 - http://www.jneurosci.org/content/17/11/4236.short 4100 - http://www.jneurosci.org/content/17/11/4236.full SO - J. Neurosci.1997 Jun 01; 17 AB - A red-blind zebrafish mutant, partial optokinetic response b (pob), has been isolated by measuring eye movements of larvae in a three-generation screen for recessive mutations affecting the visual system. pob larvae exhibit eye movements in response to rotating black and white stripes illuminated with white light, but they do not move their eyes when the stripes are illuminated with red light. Physiological, immunohistochemical, andin situ hybridization analyses of pobretinas showed a selective loss of red-sensitive cones at 5 days postfertilization (dpf). At 3 dpf, cells expressing red opsin are present, suggesting that red-sensitive cones form initially but then disappear rapidly, whereas other photoreceptors remain. Linkage analysis indicated that the mutation identified in thepob mutant is not at the red opsin locus. Because red opsin is the only known molecule unique to red cones, these data suggest that a novel gene is required for the maintenance or function of red cones.