TY - JOUR T1 - Fetal Transplants Alter the Development of Function after Spinal Cord Transection in Newborn Rats JF - The Journal of Neuroscience JO - J. Neurosci. SP - 4856 LP - 4872 DO - 10.1523/JNEUROSCI.17-12-04856.1997 VL - 17 IS - 12 AU - Dorene Miya AU - Simon Giszter AU - Futoshi Mori AU - Vijayalakshmi Adipudi AU - Alan Tessler AU - Marion Murray Y1 - 1997/06/15 UR - http://www.jneurosci.org/content/17/12/4856.abstract N2 - Pieces of fetal spinal tissue were transplanted into the site of complete midthoracic spinal transections in neonatal rat pups (transplant rats). The development of locomotion in these animals was compared with that of unoperated control rats and rats that received spinal transections alone (spinal rats). Reflex, treadmill and overground locomotion, staircase descent, and horizontal ladder crossing for a water reward were tested in control, spinal, and transplant rats from 3 weeks to adulthood. All tests were readily performed by control animals. Most spinal rats were unable to make many linked weight-supported steps on these tasks. Transplant rats were variable in their locomotor capabilities, but a subset of rats were able to demonstrate coordinated and adaptable locomotion on these tasks. Some transplant rats performed better on more challenging tasks, suggesting that motor strategies for these tasks used different information, perhaps from descending systems. Transplanted tissue survived, and in most cases there was immunocytochemical staining of serotonergic fibers passing into and caudal to the transplant, supporting the conclusion that descending systems grew through the transplanted tissue. Integration with the host tissue was often poor, suggesting that nonspecific or trophic effects of the transplant might also contribute to the development of locomotor function. Therefore several mechanisms may contribute to the repair of injured spinal cord provided by transplants that permit the development of useful locomotion. ER -