RT Journal Article SR Electronic T1 Environmental Knowledge Is Subserved by Separable Dorsal/Ventral Neural Areas JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 2512 OP 2518 DO 10.1523/JNEUROSCI.17-07-02512.1997 VO 17 IS 7 A1 Geoffrey K. Aguirre A1 Mark D’Esposito YR 1997 UL http://www.jneurosci.org/content/17/7/2512.abstract AB Environmental psychology models propose that knowledge of large-scale space is stored as distinct landmark (place appearance) and survey (place position) information. Studies of brain-damaged patients suffering from “topographical disorientation” tentatively support this proposal. In order to determine if the components of psychologically derived models of environmental representation are realized as distinct functional, neuroanatomical regions, a functional magnetic resonance imaging (fMRI) study of environmental knowledge was performed. During scanning, subjects made judgments regarding the appearance and position of familiar locations within a virtual reality environment. The fMRI data were analyzed in a manner that has been empirically demonstrated to rigorously control type I error and provide optimum sensitivity, allowing meaningful results in the single subject. A direct comparison of the survey position and landmark appearance conditions revealed a dorsal/ventral dissociation in three of four subjects. These results are discussed in the context of the observed forms of topographical disorientation and are found to be in good agreement with the human lesion studies. This experiment confirms that environmental knowledge is not represented by a unitary system but is instead functionally distributed across the neocortex.