TY - JOUR T1 - <em>Voila</em>, a New <em>Drosophila</em> Courtship Variant that Affects the Nervous System: Behavioral, Neural, and Genetic Characterization JF - The Journal of Neuroscience JO - J. Neurosci. SP - 4335 LP - 4343 DO - 10.1523/JNEUROSCI.18-11-04335.1998 VL - 18 IS - 11 AU - Maria Balakireva AU - Reinhard F. Stocker AU - Nanaë Gendre AU - Jean-François Ferveur Y1 - 1998/06/01 UR - http://www.jneurosci.org/content/18/11/4335.abstract N2 - In Drosophila melanogaster, a specificPGAL4 transposon induces theVoila1 genetic variant and produces multiple phenotypes. HomozygousVoila1/1 flies rarely reach adulthood, whereas heterozygousVoila1/+ adult males show strong bisexual behavior. Males with a single copy ofVoila1 driving the feminizing transgene UAS-transformer show very reduced sexual activity but no overall effect on their behavior.Voila1 is specifically expressed in the nervous system. In the CNS, it is expressed mainly in the mushroom bodies and, to a lesser extent, in the antennal lobes. In the peripheral nervous system, GAL4 expression is almost entirely restricted to the gustatory sensilla. Using chromosomal deficiencies, the behavioral alteration was genetically mapped to the same location as the PGAL4 element (86E1–2). The multiple behavioral effects of the Voila genetic variant are discussed in light of its expression in the nervous system and its genetic basis. ER -