PT  - JOURNAL ARTICLE
AU  - Aruga, Jun
AU  - Minowa, Osamu
AU  - Yaginuma, Hiroyuki
AU  - Kuno, Junko
AU  - Nagai, Takeharu
AU  - Noda, Tetsuo
AU  - Mikoshiba, Katsuhiko
TI  - Mouse <em>Zic1</em> Is Involved in Cerebellar Development
AID  - 10.1523/JNEUROSCI.18-01-00284.1998
DP  - 1998 Jan 01
TA  - The Journal of Neuroscience
PG  - 284--293
VI  - 18
IP  - 1
4099  - http://www.jneurosci.org/content/18/1/284.short
4100  - http://www.jneurosci.org/content/18/1/284.full
SO  - J. Neurosci.1998 Jan 01; 18
AB  - Zic genes encode zinc finger proteins, the expression of which is highly restricted to cerebellar granule cells and their precursors. These genes are homologs of theDrosophila pair-rule gene odd-paired. To clarify the role of the Zic1 gene, we have generated mice deficient in Zic1. Homozygous mice showed remarkable ataxia during postnatal development. Nearly all of the mice died within 1 month. Their cerebella were hypoplastic and missing a lobule in the anterior lobe. A bromodeoxyuridine labeling study indicated a reduction both in the proliferating cell fraction in the external germinal layer (EGL), from 14 d postcoitum, and in forward movement of the EGL. These findings suggest thatZic1 may determine the cerebellar folial pattern principally via regulation of cell proliferation in the EGL.