RT Journal Article
SR Electronic
T1 Mouse <em>Zic1</em> Is Involved in Cerebellar Development
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 284
OP 293
DO 10.1523/JNEUROSCI.18-01-00284.1998
VO 18
IS 1
A1 Aruga, Jun
A1 Minowa, Osamu
A1 Yaginuma, Hiroyuki
A1 Kuno, Junko
A1 Nagai, Takeharu
A1 Noda, Tetsuo
A1 Mikoshiba, Katsuhiko
YR 1998
UL http://www.jneurosci.org/content/18/1/284.abstract
AB Zic genes encode zinc finger proteins, the expression of which is highly restricted to cerebellar granule cells and their precursors. These genes are homologs of theDrosophila pair-rule gene odd-paired. To clarify the role of the Zic1 gene, we have generated mice deficient in Zic1. Homozygous mice showed remarkable ataxia during postnatal development. Nearly all of the mice died within 1 month. Their cerebella were hypoplastic and missing a lobule in the anterior lobe. A bromodeoxyuridine labeling study indicated a reduction both in the proliferating cell fraction in the external germinal layer (EGL), from 14 d postcoitum, and in forward movement of the EGL. These findings suggest thatZic1 may determine the cerebellar folial pattern principally via regulation of cell proliferation in the EGL.