RT Journal Article
SR Electronic
T1 Requirement for Early-Generated Neurons Recognized by Monoclonal Antibody Lot1 in the Formation of Lateral Olfactory Tract
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 7800
OP 7810
DO 10.1523/JNEUROSCI.18-19-07800.1998
VO 18
IS 19
A1 Yasufumi Sato
A1 Tatsumi Hirata
A1 Masaharu Ogawa
A1 Hajime Fujisawa
YR 1998
UL http://www.jneurosci.org/content/18/19/7800.abstract
AB During development, mitral cells, the main output neurons of the olfactory bulb, project axons into a very narrow part of the telencephalon and form an axonal bundle called the lateral olfactory tract (LOT). The present study shows that before the first mitral cell axons elongate, the LOT position is already marked with a subset of early-generated neurons that are recognized by monoclonal antibody lot1 (lot cells). Mitral cell axons choose the lot cell position for their growth pathway and maintain a close contact with the cells until LOT formation is completed. Ablation of lot cells prevented LOT formation in organotypic culture. These results suggest that lot cells are “guidepost cells” for mitral cell axons.