RT Journal Article
SR Electronic
T1 Olfactory Adaptation Depends on the Trp Ca<sup>2+</sup>Channel  in <em>Drosophila</em>
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 4839
OP 4846
DO 10.1523/JNEUROSCI.19-12-04839.1999
VO 19
IS 12
A1 Klemens F. Störtkuhl
A1 Bernhard T. Hovemann
A1 John R. Carlson
YR 1999
UL http://www.jneurosci.org/content/19/12/4839.abstract
AB Olfactory adaptation is shown to occur inDrosophila, at both behavioral and physiological levels. In a behavioral paradigm, the extent of adaptation is shown to depend on the dose and duration of the adapting stimulus. Half-maximal adaptation occurred after 15 sec of exposure to an odor, and recovery occurred with a half-time of 1.5 min, under a set of test conditions. Cross-adaptation was observed among all odor combinations tested, although to a lesser extent than when the same odor was used as both the adapting and the test stimulus. Mutants of the transient receptor potential (Trp) Ca2+ channel were normal in olfactory response, but defective in olfactory adaptation, when measured either behaviorally or in tests of antennal physiology. These results indicate that olfactory response and adaptation can be distinguished. Trp expression was detected in the developing antenna but, surprisingly, not in the mature antenna. These results, together with temperature-shift analysis of a temperature-sensitivetrp mutant, provide evidence of a role of Trp in olfactory system development.