TY - JOUR T1 - Cell-Surface Glycoprotein of Oligodendrocyte Progenitors Involved in Migration JF - The Journal of Neuroscience JO - J. Neurosci. SP - 4948 LP - 4961 DO - 10.1523/JNEUROSCI.19-12-04948.1999 VL - 19 IS - 12 AU - Antje Niehaus AU - Judith Stegmüller AU - Marianne Diers-Fenger AU - Jacqueline Trotter Y1 - 1999/06/15 UR - http://www.jneurosci.org/content/19/12/4948.abstract N2 - Myelination by oligodendrocytes in the CNS involves the migration to and recognition and ensheathment of axons. These distinct developmental phases of myelination are assumed to involve the interplay of a precisely regulated set of cell adhesion molecules expressed by both neurons and glial cells. These molecules remain largely unelucidated. In this paper we have identified a large (330 kDa) glycoprotein expressed by murine oligodendrocyte progenitor cellsin vitro and in vivo that is downregulated as oligodendrocytes mature. Antigen-positive oligodendrocyte progenitor cells purified by panning develop into myelin-associated glycoprotein-positive oligodendrocytes and also adhere to cultured neurons. Polyclonal antibodies directed against the protein reduce the migration of oligodendrocyte progenitor cells. The observations suggest that the AN2 antigen may play a role in early stages of myelination. ER -