TY - JOUR T1 - Dynamic Regulation of <em>cpg15</em> during Activity-Dependent Synaptic Development in the Mammalian Visual System JF - The Journal of Neuroscience JO - J. Neurosci. SP - 7999 LP - 8008 DO - 10.1523/JNEUROSCI.19-18-07999.1999 VL - 19 IS - 18 AU - Roderick A. Corriveau AU - Carla J. Shatz AU - Elly Nedivi Y1 - 1999/09/15 UR - http://www.jneurosci.org/content/19/18/7999.abstract N2 - During visual system development, neural activity regulates structural changes in connectivity including axonal branching and dendritic growth. Here we have examined a role for thecandidateplasticitygene15 (cpg15), which encodes an activity-regulated molecule that can promote dendritic growth, in this process. We report that cpg15 is expressed in the cat visual system at relatively high levels in the lateral geniculate nucleus (LGN) but at very low levels in its synaptic target, layer 4 of the visual cortex. Prenatally, when cpg15 mRNA in the LGN is most abundant, expression is insensitive to action potential blockade by tetrodotoxin. Postnatally, activity regulation ofcpg15 emerges in the LGN coincident with development of ocular dominance columns in the visual cortex. cpg15 can be detected in layers 2/3 and 5/6 of visual cortex postnatally, and expression in layers 2/3 is activity-regulated during known periods of activity-dependent plasticity for these layers. Localization and regulation of cpg15 expression in the visual system are consistent with a presynaptic role for CPG15 in shaping dendritic arbors of target neurons during activity-dependent synaptic rearrangements, both in development and adulthood. ER -