RT Journal Article SR Electronic T1 Synapsin III: Developmental Expression, Subcellular Localization, and Role in Axon Formation JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 3736 OP 3744 DO 10.1523/JNEUROSCI.20-10-03736.2000 VO 20 IS 10 A1 Adriana Ferreira A1 Hung-Teh Kao A1 Jian Feng A1 Mark Rapoport A1 Paul Greengard YR 2000 UL http://www.jneurosci.org/content/20/10/3736.abstract AB We have investigated the developmental expression and subcellular localization of synapsin III, the newest member of the synapsin family, in cultured mouse hippocampal neurons. Our results indicate that synapsin III is expressed early during development, with levels peaking 7 d after plating and declining thereafter. Synapsin III is highly concentrated in growth cones. Using specific antisense oligonucleotides, we have also examined the effect of depleting synapsin III on neurite elongation and synaptogenesis. When synapsin III was suppressed immediately after plating, hippocampal neurons extended minor processes but failed to differentiate one of them as the axon. The suppression of synapsin III after axonal elongation did not affect the time course of synapse formation. The results indicate that synapsin III has a developmental time course, a subcellular localization, and a developmental function very different from those of synapsin I and synapsin II.