TY - JOUR T1 - Timing Mechanisms in the Cerebellum: Testing Predictions of a Large-Scale Computer Simulation JF - The Journal of Neuroscience JO - J. Neurosci. SP - 5516 LP - 5525 DO - 10.1523/JNEUROSCI.20-14-05516.2000 VL - 20 IS - 14 AU - Javier F. Medina AU - Keith S. Garcia AU - William L. Nores AU - Nichole M. Taylor AU - Michael D. Mauk Y1 - 2000/07/15 UR - http://www.jneurosci.org/content/20/14/5516.abstract N2 - We used large-scale computer simulations of eyelid conditioning to investigate how the cerebellum generates and makes use of temporal information. In the simulations the adaptive timing displayed by conditioned responses is mediated by two factors: (1) different sets of granule cells are active at different times during the conditioned stimulus (CS), and (2) responding is not only amplified at reinforced times but also suppressed at unreinforced times during the CS. These factors predict an unusual pattern of responding after partial removal of the cerebellar cortex that was confirmed using small, electrolytic lesions of cerebellar cortex. These results are consistent with timing mechanisms in the cerebellum that are similar to Pavlov's “inhibition of delay” hypothesis. ER -