TY - JOUR T1 - Dopamine and cAMP-Regulated Phosphoprotein 32 kDa Controls Both Striatal Long-Term Depression and Long-Term Potentiation, Opposing Forms of Synaptic Plasticity JF - The Journal of Neuroscience JO - J. Neurosci. SP - 8443 LP - 8451 DO - 10.1523/JNEUROSCI.20-22-08443.2000 VL - 20 IS - 22 AU - Paolo Calabresi AU - Paolo Gubellini AU - Diego Centonze AU - Barbara Picconi AU - Giorgio Bernardi AU - Karima Chergui AU - Per Svenningsson AU - Allen A. Fienberg AU - Paul Greengard Y1 - 2000/11/15 UR - http://www.jneurosci.org/content/20/22/8443.abstract N2 - A complex chain of intracellular signaling events, critically important in motor control, is activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At corticostriatal synapses on medium spiny neurons, we provide evidence that the D1-like receptor-dependent activation of DA and cyclic adenosine 3′,5′ monophosphate-regulated phosphoprotein 32 kDa is a crucial step for the induction of both long-term depression (LTD) and long-term potentiation (LTP), two opposing forms of synaptic plasticity. In addition, formation of LTD and LTP requires the activation of protein kinase G and protein kinase A, respectively, in striatal projection neurons. These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations. ER -