RT Journal Article
SR Electronic
T1 Cannabinoid Withdrawal Syndrome Is Reduced in Pre-Proenkephalin Knock-Out Mice
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 9284
OP 9289
DO 10.1523/JNEUROSCI.20-24-09284.2000
VO 20
IS 24
A1 Olga Valverde
A1 Rafael Maldonado
A1 Emmanuel Valjent
A1 Anne M. Zimmer
A1 Andreas Zimmer
YR 2000
UL http://www.jneurosci.org/content/20/24/9284.abstract
AB The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Δ9-tetrahydrocannabinol was reduced in mutant mice, whereas no difference between genotypes was observed in the effects induced on body temperature, locomotion, or ring catalepsy. During a chronic treatment with Δ9-tetrahydrocannabinol, the development of tolerance to the analgesic responses induced by this compound was slower in mice lacking enkephalin. In addition, cannabinoid withdrawal syndrome, precipitated in Δ9-tetrahydrocannabinol-dependent mice by the injection of SR141716A, was significantly attenuated in mutant mice. These results indicate that the endogenous enkephalinergic system is involved in the antinociceptive responses of Δ9-tetrahydrocannabinol and participates in the expression of cannabinoid abstinence.