RT Journal Article SR Electronic T1 Neural Correlates of Auditory–Visual Stimulus Onset Asynchrony Detection JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 300 OP 304 DO 10.1523/JNEUROSCI.21-01-00300.2001 VO 21 IS 1 A1 Bushara, Khalafalla O. A1 Grafman, Jordan A1 Hallett, Mark YR 2001 UL http://www.jneurosci.org/content/21/1/300.abstract AB Intersensory temporal synchrony is an ubiquitous sensory attribute that has proven to be critical for binding multisensory inputs, sometimes erroneously leading to dramatic perceptual illusions. However, little is known about how the brain detects temporal synchrony between multimodal sensory inputs. We used positron emission tomography to demonstrate that detecting auditory–visual stimulus onset asynchrony activates a large-scale neural network of insular, posterior parietal, prefrontal, and cerebellar areas with the highest and task-specific activity localized to the right insula. Interregional covariance analysis further showed significant task-related functional interactions between the insula, the posterior thalamus, and superior colliculus. Based on these results and the available electrophysiological and anatomical connectivity data in animals, we propose that the insula, via its known short-latency connections with the tectal system, mediates temporally defined auditory–visual interaction at an early stage of cortical processing permitting phenomena such as the ventriloquist and the McGurk illusions.