PT  - JOURNAL ARTICLE
AU  - Michel Paré
AU  - Robert Elde
AU  - Joseph E. Mazurkiewicz
AU  - Allan M. Smith
AU  - Frank L. Rice
TI  - The Meissner Corpuscle Revised: A Multiafferented Mechanoreceptor with Nociceptor Immunochemical Properties
AID  - 10.1523/JNEUROSCI.21-18-07236.2001
DP  - 2001 Sep 15
TA  - The Journal of Neuroscience
PG  - 7236--7246
VI  - 21
IP  - 18
4099  - http://www.jneurosci.org/content/21/18/7236.short
4100  - http://www.jneurosci.org/content/21/18/7236.full
SO  - J. Neurosci.2001 Sep 15; 21
AB  - Meissner corpuscles (MCs) in the glabrous skin of monkey digits have at least three types of innervation as revealed by immunofluorescence. The previously well known Aαβ-fiber terminals are closely intertwined with endings from peptidergic C-fibers. These intertwined endings are segregated into zones that alternate with zones containing a third type of ending supplied by nonpeptidergic C-fibers. Although MCs are widely regarded as low-threshold mechanoreceptors, all three types of innervation express immunochemical properties associated with nociception. The peptidergic C-fiber endings have readily detectable levels of immunoreactivity (IR) for calcitonin gene-related peptide (CGRP) and substance P (SP). The Aαβ endings have relatively lower levels of IR for CGRP and SP as well as the SP neurokinin 1 receptor and vanilloid-like receptor 1. Both the Aαβ and peptidergic C-fiber endings were also labeled with antibodies for different combinations of adrenergic, opioid, and purinergic receptors. The nonpeptidergic C-fiber endings express IR for vanilloid receptor 1, which has also been implicated in nociception. Thus, MCs are multiafferented receptor organs that may have nociceptive capabilities in addition to being low-threshold mechanoreceptors.