RT Journal Article SR Electronic T1 Spontaneous Activity in Developing Ferret Visual Cortex In Vivo JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 8906 OP 8914 DO 10.1523/JNEUROSCI.21-22-08906.2001 VO 21 IS 22 A1 Chiu, Chiayu A1 Weliky, Michael YR 2001 UL http://www.jneurosci.org/content/21/22/8906.abstract AB Multi-electrode extracellular recordings in area 17 of awake behaving ferrets were conducted to characterize the pattern of spontaneous activity in the developing visual cortex before eye opening. A linear array of 16 microwire electrodes was used to record extracellular neuronal activity across a 3.2 mm strip of visual cortex between postnatal days 22 and 28. Whereas synchronous bursts of activity were observed at all recording sites, cross-correlation analysis revealed that the timing of spike activity at all electrodes was not precisely correlated. Correlated activity between cortical sites exhibited a patchy organization having long-range components. Long-range correlated activity was observed between cortical patches that were separated by a mean distance of 1 mm. The spatial pattern of correlated activity persisted during transient lateral geniculate nucleus (LGN) activity block, indicating that long-range correlated activity is generated by intrinsic circuits within the cortex, independent of LGN input activity. These results demonstrate an innate patchy organization of correlated spontaneous activity within the cortex during the early development of cortical functional and anatomical organization.