%0 Journal Article %A Nathalie Salichon %A Patricia Gaspar %A A. Louise Upton %A Sandrine Picaud %A Naı̈ma Hanoun %A Michel Hamon %A Edward De Maeyer %A Dennis L. Murphy %A Rainald Mössner %A Klaus Peter Lesch %A René Hen %A Isabelle Seif %T Excessive Activation of Serotonin (5-HT) 1B Receptors Disrupts the Formation of Sensory Maps in Monoamine Oxidase A and 5-HT Transporter Knock-Out Mice %D 2001 %R 10.1523/JNEUROSCI.21-03-00884.2001 %J The Journal of Neuroscience %P 884-896 %V 21 %N 3 %X Deficiency in the monoamine degradation enzyme monoamine oxidase A (MAOA) or prenatal exposure to the monoamine uptake inhibitor cocaine alters behavior in humans and rodents, but the mechanisms are unclear. In MAOA knock-out mice, inhibiting serotonin synthesis during development can prevent abnormal segregation of axons in the retinogeniculate and somatosensory thalamocortical systems. To investigate this effect, we crossed MAOA knock-outs with mice lacking the serotonin transporter 5-HTT or the 5-HT1B receptor, two molecules present in developing sensory projections. Segregation was abnormal in 5-HTT knock-outs and MAOA/5-HTT double knock-outs but was normalized in MAOA/5-HT1B double knock-outs and MAOA/5-HTT/5-HT1B triple knock-outs. This demonstrates that the 5-HT1B receptor is a key factor in abnormal segregation of sensory projections and suggests that serotonergic drugs represent a risk for the development of these projections. We also found that the 5-HT1B receptor has an adverse developmental impact on beam-walking behavior in MAOA knock-outs. Finally, because the 5-HT1B receptor inhibits glutamate release, our results suggest that visual and somatosensory projections must release glutamate for proper segregation. %U https://www.jneurosci.org/content/jneuro/21/3/884.full.pdf