PT - JOURNAL ARTICLE AU - Ko Kobayakawa AU - Reiko Hayashi AU - Kenji Morita AU - Kazunari Miyamichi AU - Yuichiro Oka AU - Akio Tsuboi AU - Hitoshi Sakano TI - Stomatin-Related Olfactory Protein, SRO, Specifically Expressed in the Murine Olfactory Sensory Neurons AID - 10.1523/JNEUROSCI.22-14-05931.2002 DP - 2002 Jul 15 TA - The Journal of Neuroscience PG - 5931--5937 VI - 22 IP - 14 4099 - http://www.jneurosci.org/content/22/14/5931.short 4100 - http://www.jneurosci.org/content/22/14/5931.full SO - J. Neurosci.2002 Jul 15; 22 AB - We identified a stomatin-related olfactory protein (SRO) that is specifically expressed in olfactory sensory neurons (OSNs). The mousesro gene encodes a polypeptide of 287 amino acids with a calculated molecular weight of 32 kDa. SRO shares 82% sequence similarity with the murine stomatin, 78% with Caenorhabditis elegans MEC-2, and 77% with C. elegans UNC-1. Unlike other stomatin-family genes, the sro transcript was present only in OSNs of the main olfactory epithelium. Nosro expression was seen in vomeronasal neurons. SRO was abundant in most apical dendrites of OSNs, including olfactory cilia. Immunoprecipitation revealed that SRO associates with adenylyl cyclase type III and caveolin-1 in the low-density membrane fraction of olfactory cilia. Furthermore, anti-SRO antibodies stimulated cAMP production in fractionated cilia membrane. SRO may play a crucial role in modulating odorant signals in the lipid rafts of olfactory cilia.