PT  - JOURNAL ARTICLE
AU  - Gorski, Jessica A.
AU  - Talley, Tiffany
AU  - Qiu, Mengsheng
AU  - Puelles, Luis
AU  - Rubenstein, John L. R.
AU  - Jones, Kevin R.
TI  - Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing Lineage
AID  - 10.1523/JNEUROSCI.22-15-06309.2002
DP  - 2002 Aug 01
TA  - The Journal of Neuroscience
PG  - 6309--6314
VI  - 22
IP  - 15
4099  - http://www.jneurosci.org/content/22/15/6309.short
4100  - http://www.jneurosci.org/content/22/15/6309.full
SO  - J. Neurosci.2002 Aug 01; 22
AB  - By homologous recombination of an internal ribosome entry site and Cre recombinase coding region into the 3′-untranslated region of the mouse Emx1 gene, we have generated a strain of mice, Emx1IREScre, that expresses the Cre recombinase in a spatial and temporal pattern like that observed for Emx1. When mated to reporter strains, these mice are a sensitive means to fate-map the Emx1-expressing cells of the developing forebrain. Our results demonstrate that radial glia, Cajal-Retzius cells, glutamatergic neurons, astrocytes, and oligodendrocytes of most pallial structures originate from an Emx1-expressing lineage. On the other hand, most of the pallial GABAergic neurons arise outside the Emx1-expressing lineage. Structures that are located near the basal ganglia (e.g., the amygdala and endopiriform nuclei) are not uniformly derived from Emx1-expressing cells.