RT Journal Article
SR Electronic
T1 Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing Lineage
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 6309
OP 6314
DO 10.1523/JNEUROSCI.22-15-06309.2002
VO 22
IS 15
A1 Gorski, Jessica A.
A1 Talley, Tiffany
A1 Qiu, Mengsheng
A1 Puelles, Luis
A1 Rubenstein, John L. R.
A1 Jones, Kevin R.
YR 2002
UL http://www.jneurosci.org/content/22/15/6309.abstract
AB By homologous recombination of an internal ribosome entry site and Cre recombinase coding region into the 3′-untranslated region of the mouse Emx1 gene, we have generated a strain of mice, Emx1IREScre, that expresses the Cre recombinase in a spatial and temporal pattern like that observed for Emx1. When mated to reporter strains, these mice are a sensitive means to fate-map the Emx1-expressing cells of the developing forebrain. Our results demonstrate that radial glia, Cajal-Retzius cells, glutamatergic neurons, astrocytes, and oligodendrocytes of most pallial structures originate from an Emx1-expressing lineage. On the other hand, most of the pallial GABAergic neurons arise outside the Emx1-expressing lineage. Structures that are located near the basal ganglia (e.g., the amygdala and endopiriform nuclei) are not uniformly derived from Emx1-expressing cells.