TY - JOUR T1 - Calcineurin Plays Different Roles in Group II Metabotropic Glutamate Receptor- and NMDA Receptor-Dependent Long-Term Depression JF - The Journal of Neuroscience JO - J. Neurosci. SP - 5034 LP - 5041 DO - 10.1523/JNEUROSCI.22-12-05034.2002 VL - 22 IS - 12 AU - Sheng-Tian Li AU - Kunio Kato AU - Kazuhito Tomizawa AU - Masayuki Matsushita AU - Akiyoshi Moriwaki AU - Hideki Matsui AU - Katsuhiko Mikoshiba Y1 - 2002/06/15 UR - http://www.jneurosci.org/content/22/12/5034.abstract N2 - We investigated metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) in hippocampal CA1 pyramidal neurons of 6- to 8-d-old [postnatal days 6–8 (P6–P8)] and 21- to 25-d-old (P21–P25) rats. In P6–P8 rats, induction of LTD depended on the activity of group II mGluRs. In P21–P25 rats, however, this LTD disappeared, and instead, NMDA receptor (NMDAR)-dependent LTD appeared. A bath containing a specific calcineurin (CaN) inhibitor restored the group II mGluR-dependent LTD in the neurons of the P21–P25 rats. Although postsynaptic injection of CaN inhibitors suppressed NMDAR-dependent LTD, it did not affect induction of group II mGluR-dependent LTD. These results demonstrate that CaN plays different roles in the induction of two forms of LTD: presynaptic CaN inhibits group II mGluR-dependent LTD, whereas postsynaptic CaN facilitates NMDAR-dependent LTD. These findings are the first demonstrationin vitro of group II mGluR-dependent LTD that is negatively regulated by CaN via an age-dependent mechanism. ER -