PT  - JOURNAL ARTICLE
AU  - Takatsuki, Kanako
AU  - Kawahara, Shigenori
AU  - Kotani, Sadaharu
AU  - Fukunaga, Satoshi
AU  - Mori, Hisashi
AU  - Mishina, Masayoshi
AU  - Kirino, Yutaka
TI  - The Hippocampus Plays an Important Role in Eyeblink Conditioning with a Short Trace Interval in Glutamate Receptor Subunit δ2 Mutant Mice
AID  - 10.1523/JNEUROSCI.23-01-00017.2003
DP  - 2003 Jan 01
TA  - The Journal of Neuroscience
PG  - 17--22
VI  - 23
IP  - 1
4099  - http://www.jneurosci.org/content/23/1/17.short
4100  - http://www.jneurosci.org/content/23/1/17.full
SO  - J. Neurosci.2003 Jan 01; 23
AB  - Mutant mice lacking the glutamate receptor subunit δ2 exhibit changes in the structure and function of the cerebellar cortex. The most prominent functional feature is a deficiency in the long-term depression (LTD) at parallel fiber–Purkinje cell synapses. These mutant mice exhibit severe impairment during delay eyeblink conditioning but learn normally during trace eyeblink conditioning without the cerebellar LTD, even with a 0 trace interval. We investigated the hippocampal contribution to this cerebellar LTD-independent “0 trace interval” learning. The mutant mice whose dorsal hippocampi were aspirated exhibited severe impairment in learning, whereas those that received post-training hippocampal lesions retained the memory. The wild-type mice showed no impairment in either case. These results suggest that the hippocampal component of the eyeblink conditioning task becomes dominant when cerebellar LTD is impaired.