RT Journal Article
SR Electronic
T1 The Hippocampus Plays an Important Role in Eyeblink Conditioning with a Short Trace Interval in Glutamate Receptor Subunit δ2 Mutant Mice
JF The Journal of Neuroscience
JO J. Neurosci.
FD Society for Neuroscience
SP 17
OP 22
DO 10.1523/JNEUROSCI.23-01-00017.2003
VO 23
IS 1
A1 Takatsuki, Kanako
A1 Kawahara, Shigenori
A1 Kotani, Sadaharu
A1 Fukunaga, Satoshi
A1 Mori, Hisashi
A1 Mishina, Masayoshi
A1 Kirino, Yutaka
YR 2003
UL http://www.jneurosci.org/content/23/1/17.abstract
AB Mutant mice lacking the glutamate receptor subunit δ2 exhibit changes in the structure and function of the cerebellar cortex. The most prominent functional feature is a deficiency in the long-term depression (LTD) at parallel fiber–Purkinje cell synapses. These mutant mice exhibit severe impairment during delay eyeblink conditioning but learn normally during trace eyeblink conditioning without the cerebellar LTD, even with a 0 trace interval. We investigated the hippocampal contribution to this cerebellar LTD-independent “0 trace interval” learning. The mutant mice whose dorsal hippocampi were aspirated exhibited severe impairment in learning, whereas those that received post-training hippocampal lesions retained the memory. The wild-type mice showed no impairment in either case. These results suggest that the hippocampal component of the eyeblink conditioning task becomes dominant when cerebellar LTD is impaired.