RT Journal Article SR Electronic T1 Synchronization of Kainate-Induced Epileptic Activity via GABAergic Inhibition in the Superfused Rat Hippocampus In Vivo JF The Journal of Neuroscience JO J. Neurosci. FD Society for Neuroscience SP 5337 OP 5341 DO 10.1523/JNEUROSCI.23-12-05337.2003 VO 23 IS 12 A1 Khazipov, Roustem A1 Holmes, Gregory L. YR 2003 UL http://www.jneurosci.org/content/23/12/5337.abstract AB We studied cellular mechanisms of synchronization of epileptiform activity induced by kainic acid in a novel preparation of superfused rat hippocampus in vivo. Under urethane anesthesia, kainate induced epileptic population spikes occurring at 30–40 Hz. Pyramidal cells fired exclusively during population spikes with an average probability of 0.34 on rebound of rhythmic GABAA-mediated inhibitory postsynaptic events. Excitatory synaptic events contributed little to seizure activity. Rhythmic epileptiform activity was suppressed by blocking GABAA receptors and was slowed by barbiturates. Thus, GABAergic inhibition is instrumental in synchronizing kainate-induced epileptiform rhythmic activity in the gamma frequency band in the intact hippocampus in vivo.