PT  - JOURNAL ARTICLE
AU  - Rose, Jacqueline K.
AU  - Kaun, Karla R.
AU  - Chen, Sylvia H.
AU  - Rankin, Catharine H.
TI  - GLR-1, a Non-NMDA Glutamate Receptor Homolog, Is Critical for Long-Term Memory in <em>Caenorhabditis elegans</em>
AID  - 10.1523/JNEUROSCI.23-29-09595.2003
DP  - 2003 Oct 22
TA  - The Journal of Neuroscience
PG  - 9595--9599
VI  - 23
IP  - 29
4099  - http://www.jneurosci.org/content/23/29/9595.short
4100  - http://www.jneurosci.org/content/23/29/9595.full
SO  - J. Neurosci.2003 Oct 22; 23
AB  - Long-term memory for habituation to tap in Caenorhabditis elegans depends on glr-1, a homolog of mammalian non-NMDA glutamate receptors; mutations in glr-1 blocked long-term memory formation. Green fluorescent protein (GFP) constructs were used to visualize glr-1 expression in the interneurons of the mechanosensory circuit and synaptobrevin in the tap sensory neurons of trained and untrained worms. Trained animals had less GLR-1::GFP expression than untrained animals; there was no difference in the vesicle marker synaptobrevin. Heat shock during training blocked both the behavioral expression of long-term memory and the change in GLR-1::GFP expression. Thus, long-term memory in C. elegans is dependent on glr-1 and likely involves changes in the expression or localization of glutamate receptors.